Endocrine Abstracts

Previously we have demonstrated up-regulated expression of COX-2 and enhanced synthesis of PGE2 in cervical carcinomas. (Sales et al. 2001. J. Clin. Endocrinol Metab. 86(5):2243-2249). Enhanced PGE2 synthesis as a consequence of COX-2 overexpression has been associated with various carcinomas and is regarded as a promoter of neoplastic cell proliferation and angiogenesis. In sexually active women growth and invasiveness of neoplastic cervical cells may be...

Prostaglandin (PG) E2 has been implicated in benign and neoplastic endometrial pathologies. PGE2 exerts its function by coupling to 4 subtypes of G protein coupled receptors (EP1-EP4). Recently a role for the EP2 receptor in angiogenesis has been established. This study investigated signal transduction and vascular endothelial growth factor (VEGF) expression by the EP2 receptor in Ishikawa endometrial epithelial cells. Ishikawa cells were stably transfect...